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Il17atm1Yiw
Targeted Allele Detail
Nomenclature
Symbol: Il17atm1Yiw
Name: interleukin 17A; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:2388010
Synonyms: IL-17-, Il17a-, IL-17A KO, IL-17-GFP, IL-17KO
Gene: Il17a  Location: Chr1:20730905-20734496 bp, + strand  Genetic Position: Chr1, 6.45 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79127
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a cassette containing an EGFP gene followed by a floxed neomycin resistance gene. Transcript was undetected by Northern blot analysis of stimulated splenic T cells derived from homozygous mutant mice. The absence of protein in T cell supernatent was determined by ELISA. (J:79127)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il17a Mutation:  8 strains or lines available
References
Original:  J:79127 Nakae S, et al., Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses. Immunity. 2002 Sep;17(3):375-387
All:  211 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory