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Mbd3tm1Bh
Targeted Allele Detail
Nomenclature
Symbol: Mbd3tm1Bh
Name: methyl-CpG binding domain protein 3; targeted mutation 1, Brian Hendrich
MGI ID: MGI:2388006
Synonyms: Mbd3(-)
Gene: Mbd3  Location: Chr10:80392539-80399531 bp, - strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68356
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-7 were replaced by an internal ribosomal entry site (IRES) followed by a betageo (beta-galactosidase/neomycin resistance) cassette via homologous recombination so that beta-galactosidase is expressed from the endogenous promoter. Homozygous mutant embryos were observed up to day E8.5. (J:68356, J:167984)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 83 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mbd3 Mutation:  54 strains or lines available
References
Original:  J:68356 Hendrich B, et al., Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev. 2001 Mar 15;15(6):710-23
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory