About   Help   FAQ
Nrcamtm1Gmt
Targeted Allele Detail
Summary
Symbol: Nrcamtm1Gmt
Name: neuronal cell adhesion molecule; targeted mutation 1, Martin Grumet
MGI ID: MGI:2387976
Synonyms: Nr-CAM
Gene: Nrcam  Location: Chr12:44375668-44648747 bp, + strand  Genetic Position: Chr12, 20.71 cM
Alliance: Nrcamtm1Gmt page
Lobes IV and V of the cerebellum are smaller in Nrcamtm1Gmt/Nrcamtm1Gmt mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71828
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, which contains the initiation codon, was replaced with a neomycin selection cassette. Western blot analysis on brain extracts derived from adult homozygous mice confirmed that no detectable protein was made from this allele. (J:71828)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 35 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrcam Mutation:  87 strains or lines available
References
Original:  J:71828 Sakurai T, et al., Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development. J Cell Biol. 2001 Sep 17;154(6):1259-73
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory