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Targeted Allele Detail
Symbol: Nrcamtm1Gmt
Name: neuronal cell adhesion molecule; targeted mutation 1, Martin Grumet
MGI ID: MGI:2387976
Synonyms: Nr-CAM
Gene: Nrcam  Location: Chr12:44328885-44601846 bp, + strand  Genetic Position: Chr12, 20.71 cM
Lobes IV and V of the cerebellum are smaller in Nrcamtm1Gmt/Nrcamtm1Gmt mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:71828
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2, which contains the initiation codon, was replaced with a neomycin selection cassette. Western blot analysis on brain extracts derived from adult homozygous mice confirmed that no detectable protein was made from this allele. (J:71828)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrcam Mutation:  37 strains or lines available
Original:  J:71828 Sakurai T, et al., Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development. J Cell Biol. 2001 Sep 17;154(6):1259-73
All:  15 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory