Atp7a^Mo-2Acre
Chemically induced Allele Detail

Summary

• Symbol: Atp7a^Mo-2Acre
• Name: ATPase, Cu++ transporting, alpha polypeptide; mottled Oak Ridge 2Acre
• MGI ID: MGI:2387947
• Synonyms: Atp7a^mo2Acre
• Gene: Atp7a Location: ChrX:105070882-105168532 bp, + strand Genetic Position: ChrX, 47.36 cM
• Alliance: Atp7a^Mo-2Acre page

Mutation origin

• Strain of Origin: T STOCK x (101 x C3H)F1

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Undefined
• Mutation details: An induced mutation that was created at The Oak Ridge National Laboratory. Strongly reduced levels of the encoded transcript are expressed from this allele.
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp7a Mutation: 69 strains or lines available

Notes

The mutation was induced by acrylamide monomer. Hemizygous males survive birth, but die within the first few weeks of life. Levels of Atp7a transcription are reduced in heterozygous females (J:38977).

References

• Original: J:38977 Cecchi C, et al., The mottled mouse as a model for human Menkes disease: identification of mutations in the Atp7a gene. (Correction: vol. 6(5):829). Hum Mol Genet. 1997 Mar;6(3):425-33
• All: 1 reference(s)