About   Help   FAQ
Iqgap1tm1Aber
Targeted Allele Detail
Nomenclature
Symbol: Iqgap1tm1Aber
Name: IQ motif containing GTPase activating protein 1; targeted mutation 1, Andre Bernards
MGI ID: MGI:2387945
Synonyms: Iqgap1-
Gene: Iqgap1  Location: Chr7:80711583-80825974 bp, - strand  Genetic Position: Chr7, 45.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59215
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of a 233 bp coding exon with a PGK-neo cassette in the reverse orientation. Complete absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of adult and embyronic tissues using antibodies raised against the N-terminal, central, and C-terminal regions of the protein. (J:59215)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Iqgap1 Mutation:  67 strains or lines available
References
Original:  J:59215 Li S, et al., Gastric hyperplasia in mice lacking the putative cdc42 effector IQGAP1. Mol Cell Biol. 2000 Jan;20(2):697-701
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory