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Targeted Allele Detail
Symbol: Iqgap1tm1Aber
Name: IQ motif containing GTPase activating protein 1; targeted mutation 1, Andre Bernards
MGI ID: MGI:2387945
Synonyms: Iqgap1-
Gene: Iqgap1  Location: Chr7:80711583-80825974 bp, - strand  Genetic Position: Chr7, 45.68 cM
Germline Transmission:  Earliest citation of germline transmission: J:59215
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of a 233 bp coding exon with a PGK-neo cassette in the reverse orientation. Complete absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of adult and embyronic tissues using antibodies raised against the N-terminal, central, and C-terminal regions of the protein. (J:59215)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Iqgap1 Mutation:  78 strains or lines available
Original:  J:59215 Li S, et al., Gastric hyperplasia in mice lacking the putative cdc42 effector IQGAP1. Mol Cell Biol. 2000 Jan;20(2):697-701
All:  16 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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