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Targeted Allele Detail
Symbol: Hey2tm1Uts
Name: hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Manuel F Utset
MGI ID: MGI:2387940
Synonyms: Hey2lacZ
Gene: Hey2  Location: Chr10:30832359-30842783 bp, - strand  Genetic Position: Chr10, 17.19 cM, cytoband A4
Germline Transmission:  Earliest citation of germline transmission: J:79025
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment, extending from codon 19 in exon 1 through a portion of exon 3, was replaced with a cassette containing lacZ and neo. The deleted region encoded the basic helix-loop-helix, Orange, and YXXW domains. The expression pattern of the fusion protein containing lacZ was similar to that of the endogenous pattern. (J:79025)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hey2 Mutation:  5 strains or lines available
Original:  J:79025 Donovan J, et al., Tetralogy of fallot and other congenital heart defects in hey2 mutant mice. Curr Biol. 2002 Sep 17;12(18):1605
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory