Adcy5^tm1Plhn
Targeted Allele Detail

Summary

• Symbol: Adcy5^tm1Plhn
• Name: adenylate cyclase 5; targeted mutation 1, Pyung-Lim Han
• MGI ID: MGI:2387896
• Synonyms: AC5^-
• Gene: Adcy5 Location: Chr16:34975247-35126108 bp, + strand Genetic Position: Chr16, 24.71 cM, cytoband B-5
• Alliance: Adcy5^tm1Plhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79146
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' portion of exon 2 was replaced by a neomycin selection cassette inserted by homologous recombination. Northern and Western blot analyses confirmed the absence of transcript and protein in homozygous mutant mice. (J:79146)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adcy5 Mutation: 66 strains or lines available

References

• Original: J:79146 Lee KW, et al., Impaired d2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. J Neurosci. 2002 Sep 15;22(18):7931-40
• All: 20 reference(s)