Tnni3^tm1Jww
Targeted Allele Detail

Summary

• Symbol: Tnni3^tm1Jww
• Name: troponin I, cardiac 3; targeted mutation 1, Jeffery W Walker
• MGI ID: MGI:2387868
• Synonyms: cTnI-
• Gene: Tnni3 Location: Chr7:4521304-4526228 bp, - strand Genetic Position: Chr7, 2.61 cM
• Alliance: Tnni3^tm1Jww page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53628
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene (exon 1-8) was replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis. (J:53628)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnni3 Mutation: 14 strains or lines available

References

• Original: J:53628 Huang X, et al., Cardiac troponin I gene knockout: a mouse model of myocardial troponin I deficiency [see comments]. Circ Res. 1999 Jan 8-22;84(1):1-8
• All: 15 reference(s)