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Rad50tm1Jpt
Targeted Allele Detail
Nomenclature
Symbol: Rad50tm1Jpt
Name: RAD50 homolog (S. cerevisiae); targeted mutation 1, John H J Petrini
MGI ID: MGI:2387852
Synonyms: m1, mrad50Brdm1, Rad50delta
Gene: Rad50  Location: Chr11:53649519-53707319 bp, - strand  Genetic Position: Chr11, 31.98 cM, cytoband A5-B1
Development of Rad50tm1Jpt/Rad50tm1Jpt embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56083
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by replacement of exon 1 with a PGK-neo cassette via homologous recombination. Homozygous mutant embryos were identified by PCR genotyping. (J:56083)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rad50 Mutation:  5 strains or lines available
References
Original:  J:56083 Luo G, et al., Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7376-81
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory