Vav1^tm1Bbd
Targeted Allele Detail

Summary

• Symbol: Vav1^tm1Bbd
• Name: vav 1 oncogene; targeted mutation 1, Mariano Barbacid
• MGI ID: MGI:2387839
• Synonyms: vav (-)
• Gene: Vav1 Location: Chr17:57586100-57635031 bp, + strand Genetic Position: Chr17, 29.76 cM
• Alliance: Vav1^tm1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22517
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding amino acids 135-195 comprising the entire acidic domain were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant embryos were identified by PCR genotype analysis at day E3.5, but not at days E7.5-E12.5. (J:22517)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav1 Mutation: 58 strains or lines available

References

• Original: J:22517 Zmuidzinas A, et al., The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro. EMBO J. 1995 Jan 3;14(1):1-11
• All: 1 reference(s)