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Targeted Allele Detail
Symbol: Vav1tm1Bbd
Name: vav 1 oncogene; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:2387839
Synonyms: vav (-)
Gene: Vav1  Location: Chr17:57279100-57328031 bp, + strand  Genetic Position: Chr17, 29.76 cM
Germline Transmission:  Earliest citation of germline transmission: J:22517
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequences encoding amino acids 135-195 comprising the entire acidic domain were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant embryos were identified by PCR genotype analysis at day E3.5, but not at days E7.5-E12.5. (J:22517)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vav1 Mutation:  31 strains or lines available
Original:  J:22517 Zmuidzinas A, et al., The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro. EMBO J. 1995 Jan 3;14(1):1-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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