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Targeted Allele Detail
Symbol: Vav1tm1Tyb
Name: vav 1 oncogene; targeted mutation 1, Victor L J Tybulewicz
MGI ID: MGI:2387838
Synonyms: Vav-, Vav1-
Gene: Vav1  Location: Chr17:57279100-57328031 bp, + strand  Genetic Position: Chr17, 29.76 cM
Germline Transmission:  Earliest citation of germline transmission: J:79323
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette into a coding exon at nucleotide 793. No full-length or partial protein product was detectable in thymocytes and splenic B and T cells from homozygous mutant animals via Western blot analysis. (J:79324, J:97055)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Vav1 Mutation:  38 strains or lines available
Original:  J:79323 Turner M, et al., A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity. 1997 Oct;7(4):451-60
All:  83 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory