About   Help   FAQ
Vav1tm1Tyb
Targeted Allele Detail
Nomenclature
Symbol: Vav1tm1Tyb
Name: vav 1 oncogene; targeted mutation 1, Victor L J Tybulewicz
MGI ID: MGI:2387838
Synonyms: Vav-, Vav1-
Gene: Vav1  Location: Chr17:57279100-57328031 bp, + strand  Genetic Position: Chr17, 29.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79323
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette into a coding exon at nucleotide 793. No full-length or partial protein product was detectable in thymocytes and splenic B and T cells from homozygous mutant animals via Western blot analysis. (J:79324, J:97055)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vav1 Mutation:  31 strains or lines available
References
Original:  J:79323 Turner M, et al., A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity. 1997 Oct;7(4):451-60
All:  79 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/14/2017
MGI 6.11
The Jackson Laboratory