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Odc1tm1Jlc
Targeted Allele Detail
Nomenclature
Symbol: Odc1tm1Jlc
Name: ornithine decarboxylase, structural 1; targeted mutation 1, John L Cleveland
MGI ID: MGI:2387837
Synonyms: ODC-
Gene: Odc1  Location: Chr12:17544808-17551502 bp, + strand  Genetic Position: Chr12, 8.11 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71462
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of exon 2 and all of exon 3 were replaced with an IRES-lacz-neo cassette. The deleted region encoded the first 35 amino acids of the endogenous protein, including the initiator methionine. A biochemical assay of extracts obtained from MEFs derived from heterozygous animals, showed enzymatic activity to be reduced by approximately half. (J:71462)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Odc1 Mutation:  21 strains or lines available
References
Original:  J:71462 Pendeville H, et al., The ornithine decarboxylase gene is essential for cell survival during early murine development. Mol Cell Biol. 2001 Oct;21(19):6549-58
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory