Sftpctm1Swg
Targeted Allele Detail
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Nomenclature |
| Symbol: |
Sftpctm1Swg |
| Name: |
surfactant associated protein C; targeted mutation 1, Stephan W Glasser |
| MGI ID: |
MGI:2387813 |
| Synonyms: |
SP-C(-) |
| Gene: |
Sftpc Location: Chr14:70520941-70524081 bp, - strand Genetic Position: Chr14, 36.32 cM
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Airspace remodeling, stromal thickening and monocytic infiltration in the lungs of Sftpctm1Swg/Sftpctm1Swg mice
Show the 6 phenotype image(s) involving this allele.
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Mutation
origin |
| Germline Transmission: |
Earliest citation of germline transmission:
J:69619
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
129/Sv |
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Mutation
description |
| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 2. No mature mRNA was detected in homozygous mutant animals via Northern blot of lung tissue, but a faint band of smaller size was observed. RT-PCR and sequence analysis revealed the product was an alternatively spliced transcript from exon 1 to exon 3, bypassing exon 2. No protein product was detected in alveolar lavage from homozygous mutant animals.
(J:69619)
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Phenotypes |
View phenotypes for all genotypes (concatenated display).
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Disease models |
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Find Mice (IMSR) |
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Sftpc Mutation: |
4 strains or lines available
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Notes |
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References |
| Original: |
J:69619 Glasser SW, et al., Altered stability of pulmonary surfactant in SP-C-deficient mice. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6366-71 |
| All: |
6 reference(s) |
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Analysis Tools
