Sftpc^tm1Swg
Targeted Allele Detail

Nomenclature

Symbol:	Sftpc^tm1Swg
Name:	surfactant associated protein C; targeted mutation 1, Stephan W Glasser
MGI ID:	MGI:2387813
Synonyms:	SP-C(-)
Gene:	Sftpc  Location: Chr14:70520941-70524081 bp, - strand  Genetic Position: Chr14, 36.32 cM

Airspace remodeling, stromal thickening and monocytic infiltration in the lungs of Sftpc^tm1Swg/Sftpc^tm1Swg mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

Germline Transmission:	Earliest citation of germline transmission: J:69619
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129/Sv

Mutation description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 2. No mature mRNA was detected in homozygous mutant animals via Northern blot of lung tissue, but a faint band of smaller size was observed. RT-PCR and sequence analysis revealed the product was an alternatively spliced transcript from exon 1 to exon 3, bypassing exon 2. No protein product was detected in alveolar lavage from homozygous mutant animals. (J:69619)

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sftpc Mutation:	0 strains or lines available

Notes

ES cell line = D3R.

References

Original:	J:69619 Glasser SW, et al., Altered stability of pulmonary surfactant in SP-C-deficient mice. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6366-71
All:	6 reference(s)