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Targeted Allele Detail
Symbol: Sftpctm1Swg
Name: surfactant associated protein C; targeted mutation 1, Stephan W Glasser
MGI ID: MGI:2387813
Synonyms: SP-C(-)
Gene: Sftpc  Location: Chr14:70520941-70524081 bp, - strand  Genetic Position: Chr14, 36.32 cM
Airspace remodeling, stromal thickening and monocytic infiltration in the lungs of Sftpctm1Swg/Sftpctm1Swg mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:69619
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette into exon 2. No mature mRNA was detected in homozygous mutant animals via Northern blot of lung tissue, but a faint band of smaller size was observed. RT-PCR and sequence analysis revealed the product was an alternatively spliced transcript from exon 1 to exon 3, bypassing exon 2. No protein product was detected in alveolar lavage from homozygous mutant animals. (J:69619)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sftpc Mutation:  1 strain or line available
ES cell line = D3R.

Original:  J:69619 Glasser SW, et al., Altered stability of pulmonary surfactant in SP-C-deficient mice. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6366-71
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory