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Targeted Allele Detail
Symbol: Mertktm1Gkm
Name: MER proto-oncogene tyrosine kinase; targeted mutation 1, Glenn K Matsushima
MGI ID: MGI:2387768
Synonyms: Mer-, merkd, MERKO, mertkkd
Gene: Mertk  Location: Chr2:128698956-128802894 bp, + strand  Genetic Position: Chr2, 62.63 cM
Mononuclear cell infiltration of the large intestines and salivary glands are reduced in Mertktm1Gkm/Mertktm1Gkm mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:53423
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced sequences including the last exon, which encodes the carboxy terminal end of the kinase domain and the cytoplasmic tail. RT-PCR analysis demonstrated that a mutant transcript was expressed from this allele that lacked sequences encoding the cytoplasmic kinase domain. (J:53423, J:153843)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mertk Mutation:  5 strains or lines available
Original:  J:53423 Camenisch TD, et al., A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock. J Immunol. 1999 Mar 15;162(6):3498-503
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory