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Targeted Allele Detail
Symbol: Mertktm1Gkm
Name: c-mer proto-oncogene tyrosine kinase; targeted mutation 1, Glenn K Matsushima
MGI ID: MGI:2387768
Synonyms: Mer-, merkd, MERKO, mertkkd
Gene: Mertk  Location: Chr2:128698956-128802894 bp, + strand  Genetic Position: Chr2, 62.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:53423
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced sequences including the last exon, which encodes the carboxy terminal end of the kinase domain and the cytoplasmic tail. RT-PCR analysis demonstrated that a mutant transcript was expressed from this allele that lacked sequences encoding the cytoplasmic kinase domain. (J:53423, J:153843)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mertk Mutation:  33 strains or lines available
Original:  J:53423 Camenisch TD, et al., A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock. J Immunol. 1999 Mar 15;162(6):3498-503
All:  32 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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