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Targeted Allele Detail
Symbol: Dcxtm1Caw
Name: doublecortin; targeted mutation 1, Christopher A Walsh
MGI ID: MGI:2387757
Synonyms: Dcx-
Gene: Dcx  Location: ChrX:142638838-142716307 bp, - strand  Genetic Position: ChrX, 64.89 cM
Hippocampal disorganization, increased c-fos, and loss of SOM+ interneurons in Dcxtm1Caw/Y Dclk2tm1.2Jgg/Dclk2tm1.2Jgg mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:78746
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 and 3 were replaced by a cassette containing lacZ and neo inserted by homologous recombination. The deleted region encodes the microtubule binding and bundling properties of the protein. Western blot and immunohistochemical analyses showed an absence of protein in hemizygous mutant male mice and reduced levels in heterozygous mutant female mice, indicating that protein is not produced by the targeted loci. Expression of the lacZ gene was driven by the endogenous promoter. (J:78746)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 56 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dcx Mutation:  16 strains or lines available
Original:  J:78746 Corbo JC, et al., Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci. 2002 Sep 1;22(17):7548-57
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
The Jackson Laboratory