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Axltm1Grl
Targeted Allele Detail
Nomenclature
Symbol: Axltm1Grl
Name: AXL receptor tyrosine kinase; targeted mutation 1, Greg Lemke
MGI ID: MGI:2387750
Synonyms: Axl-
Gene: Axl  Location: Chr7:25757273-25788705 bp, - strand  Genetic Position: Chr7, 14.02 cM, cytoband A3-B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54681
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a segment of the gene containing exon 9. Western blot analysis on total brain lysates derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:54681)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Axl Mutation:  4 strains or lines available
References
Original:  J:54681 Lu Q, et al., Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature. 1999 Apr 22;398(6729):723-8
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory