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Thrsptm1Cnm
Targeted Allele Detail
Nomenclature
Symbol: Thrsptm1Cnm
Name: thyroid hormone responsive; targeted mutation 1, Cary N Mariash
MGI ID: MGI:2387689
Gene: Thrsp  Location: Chr7:97412938-97417730 bp, - strand  Genetic Position: Chr7, 53.49 cM, cytoband E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71785
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of a large portion of exon 1 with a PGK-neo cassette. The targeted mutation deletes sequences encoding amino acids 22-150. Northern blot analysis and quantitative RT-PCR was unable to detect gene transcripts from hepatic mRNA of homozygous mutant animals, thus confirming the null allele. (J:71785)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thrsp Mutation:  16 strains or lines available
References
Original:  J:71785 Zhu Q, et al., Spot 14 Gene Deletion Increases Hepatic de Novo Lipogenesis. Endocrinology. 2001 Oct;142(10):4363-70
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory