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G6pdxtm1Luz
Targeted Allele Detail
Nomenclature
Symbol: G6pdxtm1Luz
Name: glucose-6-phosphate dehydrogenase X-linked; targeted mutation 1, Lucio Luzzatto
MGI ID: MGI:2387672
Synonyms: G6PD(-)
Gene: G6pdx  Location: ChrX:74409483-74428880 bp, - strand  Genetic Position: ChrX, 38.0 cM, cytoband A2-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78546
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted proximally to exon 3 via homologous recombination. Northern blot analysis of ES cells showed normal length transcript present at approximately 5% of wild-type levels. Subsequent sequence analysis identified a slice site between the neo cassette and exon 3, allowing a low rate of normal splicing to occur. (J:78546, J:79389)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any G6pdx Mutation:  6 strains or lines available
References
Original:  J:78546 Longo L, et al., Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal. EMBO J. 2002 Aug 15;21(16):4229-39
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory