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Targeted Allele Detail
Symbol: Trpc4tm1Bni
Name: transient receptor potential cation channel, subfamily C, member 4; targeted mutation 1, Bernd Nilius
MGI ID: MGI:2387666
Synonyms: TRP4-/-
Gene: Trpc4  Location: Chr3:54156035-54318471 bp, + strand  Genetic Position: Chr3, 25.43 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:68178
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details278 bp of the exon encoding transmembrane domains 4 and 5 and the adjacent downstream splice donor site were replaced with a PGK-neo cassette in the reverse transcriptional orientation. Northern blot and Western blot of brain homogenates and primary mouse vascular endothelial cells (MAECs) cultured from homozygous mutant animals confirmed the absence of gene expression. (J:68178)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpc4 Mutation:  27 strains or lines available
Original:  J:68178 Freichel M, et al., Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice. Nat Cell Biol. 2001 Feb;3(2):121-7
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory