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Igh-7tm1Led
Targeted Allele Detail
Nomenclature
Symbol: Igh-7tm1Led
Name: immunoglobulin heavy chain 7 (heavy chain of IgE); targeted mutation 1, Philip Leder
MGI ID: MGI:2387579
Synonyms: IgE-
Gene: Igh-7  Location: Chr12:113264521-113277715 bp  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:19552
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 4 were replaced by a neomycin selection cassette inserted via homologous recombination. Transcript was undetected by Northern blot analysis of splenocytes obtained from homozygous mutant mice and stimulated with interleukin-4 and LPS. ELISA confirmed the absence of IgE. (J:19552)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh-7 Mutation:  0 strains or lines available
References
Original:  J:19552 Oettgen HC, et al., Active anaphylaxis in IgE-deficient mice. Nature. 1994 Aug 4;370(6488):367-70
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory