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Targeted Allele Detail
Symbol: Zeb2tm1.2Yhi
Name: zinc finger E-box binding homeobox 2; targeted mutation 1.2, Yujiro Higashi
MGI ID: MGI:2387501
Synonyms: SIP1delta ex7, Zfhx1bdeltaex7
Gene: Zeb2  Location: Chr2:44873644-45007407 bp, - strand  Genetic Position: Chr2, 27.31 cM, cytoband C1
Alliance: Zeb2tm1.2Yhi page
Germline Transmission:  Earliest citation of germline transmission: J:75138
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 7, which encodes the fourth zinc finger of the amino terminal zinc finger cluster, the Madh binding domain, the homeodomain like sequence, and the CtBP binding sites, were deleted along with a floxed neo cassette by in vivo cre recombination of Zhx1btm1Yhi. The absence of protein was confirmed by Western blot analysis of homozygous mutant mice. (J:75138)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 30 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zeb2 Mutation:  38 strains or lines available
Original:  J:75138 Higashi Y, et al., Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse. Genesis. 2002 Feb;32(2):82-4
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory