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Rps6ka3tm1Ljg
Targeted Allele Detail
Nomenclature
Symbol: Rps6ka3tm1Ljg
Name: ribosomal protein S6 kinase polypeptide 3; targeted mutation 1, Laurie J Goodyear
MGI ID: MGI:2387473
Synonyms: Rsk2-, Rsk2 KO
Gene: Rps6ka3  Location: ChrX:159210307-159368244 bp, + strand  Genetic Position: ChrX, 73.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67575
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encoding 31 residues of the amino terminal kinase domain were replaced with a neomycin selection cassette. Western blot analysis of muscle lysates confirmed the absence of normal protein in homozygous mutant mice. (J:67575)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rps6ka3 Mutation:  8 strains or lines available
References
Original:  J:67575 Dufresne SD, et al., Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Mol Cell Biol. 2001 Jan;21(1):81-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory