Pthlh^tm1Ack
Targeted Allele Detail

Summary

• Symbol: Pthlh^tm1Ack
• Name: parathyroid hormone-like peptide; targeted mutation 1, Andrew C Karaplis
• MGI ID: MGI:2387462
• Synonyms: Pthrp^flox, PTHrP^L2
• Gene: Pthlh Location: Chr6:147153607-147165511 bp, - strand Genetic Position: Chr6, 78.19 cM, cytoband F-G
• Alliance: Pthlh^tm1Ack page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69396
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was left flanked by single loxP sites after a downstream floxed selection cassette was removed via in vitro cre mediated excison. (J:69396)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pthlh Mutation: 19 strains or lines available

References

• Original: J:69396 He B, et al., Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles. Endocrinology. 2001 May;142(5):2070-7
• All: 17 reference(s)