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Htr1atm1Toth
Targeted Allele Detail
Nomenclature
Symbol: Htr1atm1Toth
Name: 5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 1, Miklos Toth
MGI ID: MGI:2387408
Synonyms: 5-HT(1A)-KO, 5-HT1A KO
Gene: Htr1a  Location: Chr13:105443693-105448133 bp, + strand  Genetic Position: Chr13, 56.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49752
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin selection cassette deleted the start codon and 123 bp of coding sequence. Autoradiograhy analysis showed an absence of binding in coronal sections from homozygous mutant mice. (J:49752)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr1a Mutation:  14 strains or lines available
References
Original:  J:49752 Parks CL, et al., Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10734-9
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory