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Htr1atm1Rhn
Targeted Allele Detail
Nomenclature
Symbol: Htr1atm1Rhn
Name: 5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 1, Rene Hen
MGI ID: MGI:2387407
Synonyms: 5-HT1A
Gene: Htr1a  Location: Chr13:105443693-105448133 bp, + strand  Genetic Position: Chr13, 56.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51280
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe endogenous locus was disrupted by the insertion of a neomycin selection cassette downstream of sequence encoding the third transmembrane domain. Homozygous mutant mice were shown to lack functional receptors via autoradiography studies of brain sections. (J:51280)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr1a Mutation:  5 strains or lines available
References
Original:  J:51280 Ramboz S, et al., Serotonin receptor 1A knockout: an animal model of anxiety-related disorder [see comments]. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14476-81
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory