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Stk11tm1.2Rdp
Targeted Allele Detail
Nomenclature
Symbol: Stk11tm1.2Rdp
Name: serine/threonine kinase 11; targeted mutation 1.2, Ronald DePinho
MGI ID: MGI:2387403
Synonyms: Lkb1-
Gene: Stk11  Location: Chr10:80115803-80130682 bp, + strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78818
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 through 6 were excised from Stk11tm1Rdp via the in vivo expression of cre recombinase. Protein was undetected by Western blot analysis of mouse embyronic fibroblasts derived from homozygous mutant mice. (J:78818)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk11 Mutation:  21 strains or lines available
Notes

Phenotypic Similarity to Human Syndrome: Non-Small-Cell Lung Carcinoma J:124682 in double Kras and Stk11 mutants.

References
Original:  J:78818 Bardeesy N, et al., Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002 Sep 12;419(6903):162-7
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory