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Targeted Allele Detail
Symbol: Stk11tm1.1Rdp
Name: serine/threonine kinase 11; targeted mutation 1.1, Ronald DePinho
MGI ID: MGI:2387402
Synonyms: Lkb1L, Lkb1lox
Gene: Stk11  Location: Chr10:80115803-80130682 bp, + strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:78818
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe frt flanked neo cassette was excised from intron 2 of Stk11tm1Rdp by the in vivo expression of flp recombinase. Exons 3 through 6 were left flanked by single loxP sites in introns 2 and 6. (J:78818)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk11 Mutation:  7 strains or lines available
Original:  J:78818 Bardeesy N, et al., Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002 Sep 12;419(6903):162-7
All:  81 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory