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Stk11tm1Rdp
Targeted Allele Detail
Summary
Symbol: Stk11tm1Rdp
Name: serine/threonine kinase 11; targeted mutation 1, Ronald DePinho
MGI ID: MGI:2387401
Synonyms: Lkb1c, Lkb1f, STK11fl
Gene: Stk11  Location: Chr10:79951637-79966516 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Stk11tm1Rdp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78818
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 3 through 6 were flanked by single loxP sites inserted into introns 2 and 6. In addition a neo cassette flanked by frt sites was inserted into intron 2, downstream of the loxP site. Mice carrying this allele were used to generate Stk11tm1.1Rdp and Stk11tm1.2Rdp. (J:78818)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 208072 assay results
4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Stk11tm1Rdp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stk11 Mutation:  34 strains or lines available
References
Original:  J:78818 Bardeesy N, et al., Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002 Sep 12;419(6903):162-7
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory