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Tcf4tm1Zhu
Targeted Allele Detail
Summary
Symbol: Tcf4tm1Zhu
Name: transcription factor 4; targeted mutation 1, Yuan Zhuang
MGI ID: MGI:2387399
Synonyms: E2-2-, Tcf4-
Gene: Tcf4  Location: Chr18:69476500-69821038 bp, + strand  Genetic Position: Chr18, 43.23 cM, cytoband E2
Alliance: Tcf4tm1Zhu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43324
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin selection cassette deleted sequence encoding the carboxy terminal, including a portion of the basic helix-loop-helix (bHLH) domain. The disruption of the bHLH precludes dimerization, thereby preventing the potential for DNA binding activity. (J:43324)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tcf4 Mutation:  36 strains or lines available
Notes
ES cell line = EFC-1.
References
Original:  J:43324 Zhuang Y, et al., B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol. 1996 Jun;16(6):2898-905
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/26/2022
MGI 6.22
The Jackson Laboratory