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Dag1tm2Kcam
Targeted Allele Detail
Nomenclature
Symbol: Dag1tm2Kcam
Name: dystroglycan 1; targeted mutation 2, Kevin P Campbell
MGI ID: MGI:2387358
Synonyms: Dag1flox, Dag1L, Dag1lox, DG-flox, DGlox, DG (lox)
Gene: Dag1  Location: Chr9:108204861-108263958 bp, - strand  Genetic Position: Chr9, 59.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78838
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 2 was floxed by introducing a loxP site downstream of exon 2 and by inserting a floxed neo cassette into the upstream intron via homologous recombination. (J:78838)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dag1 Mutation:  96 strains or lines available
References
Original:  J:78838 Cohn RD, et al., Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cell. 2002 Sep 6;110(5):639-48
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory