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Targeted Allele Detail
Symbol: Adipoqtm1Ish
Name: adiponectin, C1Q and collagen domain containing; targeted mutation 1, Iichiro Shimomura
MGI ID: MGI:2387344
Synonyms: Adipo-, APN-KO
Gene: Adipoq  Location: Chr16:23146536-23157968 bp, + strand  Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
Germline Transmission:  Earliest citation of germline transmission: J:77479
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsParts of introns 1 and 2, and regions of exon 2, which contains the translation initiation sites, were replaced by a neomycin resistance gene via homologous recombination. Absence of gene expression in adipose tissues of homozygous mutant animals was confirmed by Northern blot analysis. Protein product was undetectable in plasma of homozygous mutants. (J:77479)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 21 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adipoq Mutation:  29 strains or lines available
Original:  J:77479 Maeda N, et al., Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med. 2002 Jul;8(7):731-7
All:  78 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory