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Targeted Allele Detail
Symbol: Brca2tm1Mbn
Name: breast cancer 2, early onset; targeted mutation 1, L Michelle Bennett
MGI ID: MGI:2387337
Synonyms: B2-, Brca2 delta10/11
Gene: Brca2  Location: Chr5:150522630-150570329 bp, + strand  Genetic Position: Chr5, 89.52 cM
Germline Transmission:  Earliest citation of germline transmission: J:74077
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsNucleotides 1745 to 2033, encompassing portions of exons 10 and 11 and the intervening intron, were replaced with a neomycin selection cassette. RT-PCR and sequence analyses identified an aberrant transcript containing the first 569 codons of the endogenous gene fused to 75 neo codons. This transcript was undetected by Northern blot analysis, indicating that it was unstable. (J:74077)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:  33 strains or lines available
Original:  J:74077 Bennett LM, et al., BRCA2-null embryonic survival is prolonged on the BALB/c genetic background. Mol Carcinog. 2000 Jul;28(3):174-83
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory