Foxe3^rct
Spontaneous Allele Detail

Summary

• Symbol: Foxe3^rct
• Name: forkhead box E3; Rinshoken cataract
• MGI ID: MGI:2387330
• Gene: Foxe3 Location: Chr4:114782344-114783210 bp, - strand Genetic Position: Chr4, 52.73 cM, cytoband C7
• Alliance: Foxe3^rct page

Slit-lamp photographs of eyes of 4 month old SJL/J and rct/rct mice.

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: SJL/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: Mice exhibit a spontaneous deletion of 22 bp in a highly conserved region upstream of the gene in a major lens regulatory element. RT-PCR analysis of eye extracts confirmed reduced transcript expression. (J:177496)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxe3 Mutation: 15 strains or lines available

References

• Original: J:68340 Maeda YY, et al., Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Mamm Genome. 2001 Apr;12(4):278-83
• All: 3 reference(s)