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Foxe3rct
Spontaneous Allele Detail
Nomenclature
Symbol: Foxe3rct
Name: forkhead box E3; Rinshoken cataract
MGI ID: MGI:2387330
Gene: Foxe3  Location: Chr4:114925147-114926013 bp, - strand  Genetic Position: Chr4, 52.73 cM, cytoband C7
Slit-lamp photographs of eyes of 4 month old SJL/J and rct/rct mice.

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  SJL/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsMice exhibit a spontaneous deletion of 22 bp in a highly conserved region upstream of the gene in a major lens regulatory element. RT-PCR analysis of eye extracts confirmed reduced transcript expression. (J:177496)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxe3 Mutation:  7 strains or lines available
References
Original:  J:68340 Maeda YY, et al., Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Mamm Genome. 2001 Apr;12(4):278-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory