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Dnase1tm1Tmo
Targeted Allele Detail
Nomenclature
Symbol: Dnase1tm1Tmo
Name: deoxyribonuclease I; targeted mutation 1, Tarik Moroy
MGI ID: MGI:2387029
Synonyms: Dnase1-
Gene: Dnase1  Location: Chr16:4036942-4040024 bp, + strand  Genetic Position: Chr16, 2.37 cM, cytoband A1-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62549
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAll 9 exons were removed and replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of RNA from parotids, kidney, and small intestine from homozygous mutant animals, using a rat cDNA probe, did not detect gene expression. Zymograms of cell extracts from parotids, small intestines, kidneys, urine, and serum of homozygous animals demonstrated the absence of enzyme activity. (J:62549)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnase1 Mutation:  2 strains or lines available
References
Original:  J:62549 Napirei M, et al., Features of systemic lupus erythematosus in Dnase1-deficient mice [see comments]. Nat Genet. 2000 Jun;25(2):177-81
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory