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Stk11tm1Tpm
Targeted Allele Detail
Nomenclature
Symbol: Stk11tm1Tpm
Name: serine/threonine kinase 11; targeted mutation 1, Tomi P Makela
MGI ID: MGI:2387003
Synonyms: Lkb1-
Gene: Stk11  Location: Chr10:80115803-80130682 bp, + strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70892
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exons 2 through 7 were replaced with a neomycin selection cassette by homologous recombination. (J:70892)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk11 Mutation:  5 strains or lines available
References
Original:  J:70892 Ylikorkala A, et al., Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science. 2001 Aug 17;293(5533):1323-6
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory