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Il6sttm2Thir
Targeted Allele Detail
Nomenclature
Symbol: Il6sttm2Thir
Name: interleukin 6 signal transducer; targeted mutation 2, Toshio Hirano
MGI ID: MGI:2386993
Synonyms: gp130FXXQ
Gene: Il6st  Location: Chr13:112464070-112506860 bp, + strand  Genetic Position: Chr13, 63.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59922
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsA human Il6st cDNA fragment carrying tyrosine to phenylalanine substitutions at amino acids 767, 814, 905, and 915, was used to replaced the corresponding region of the mouse gene. A downstream neomycin resistance cassette was also inserted for positive selection. (J:59922)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il6st Mutation:  28 strains or lines available
References
Original:  J:59922 Ohtani T, et al., Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000 Jan;12(1):95-105
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory