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Targeted Allele Detail
Symbol: Stk10tm1Hkar
Name: serine/threonine kinase 10; targeted mutation 1, Hajime Karasuyama
MGI ID: MGI:2386974
Synonyms: lok-/-
Gene: Stk10  Location: Chr11:32533305-32624587 bp, + strand  Genetic Position: Chr11, 18.97 cM, cytoband A4
Germline Transmission:  Earliest citation of germline transmission: J:60738
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Western blot analysis of splenocytes from homozygous mutant animals confirmed the absence of gene expression. (J:60738)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk10 Mutation:  27 strains or lines available
Original:  J:60738 Endo J, et al., Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. FEBS Lett. 2000 Feb 25;468(2-3):234-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory