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Targeted Allele Detail
Symbol: Traf1tm1Tsi
Name: TNF receptor-associated factor 1; targeted mutation 1, Erdyni Y Tsitsikov
MGI ID: MGI:2386957
Synonyms: TRAF1-
Gene: Traf1  Location: Chr2:34941750-34961772 bp, - strand  Genetic Position: Chr2, 23.13 cM
Germline Transmission:  Earliest citation of germline transmission: J:72327
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exons 2-5 with a neomycin resistance cassette. Homozygous mutant animals did not express protein product as determined by Western blot analysis of stimulated splenocytes using polyclonal antibodies directed against the C-terminus of the protein. (J:72327)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Traf1 Mutation:  5 strains or lines available
Original:  J:72327 Tsitsikov EN, et al., Traf1 is a negative regulator of tnf signaling. enhanced tnf signaling in traf1-deficient mice. Immunity. 2001 Oct;15(4):647-57
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory