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Ror2tm1Gdy
Targeted Allele Detail
Nomenclature
Symbol: Ror2tm1Gdy
Name: receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1, George D Yancopoulos
MGI ID: MGI:2386954
Synonyms: Ror2-, Ror2TMlacZ
Gene: Ror2  Location: Chr13:53109317-53286124 bp, - strand  Genetic Position: Chr13, 27.68 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60754
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of the thymidine kinase-like domain with a lacZ-neo cassette resulting in the fusion of the ecto- and transmembrane-domains with lacZ. Beta-gal staining of mutant embryo sections and in situ hybridization analysis confirmed expression of the fusion product is similar to that of the endogenous protein. (J:60754)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 21 assay results
In Structures Affected by this Mutation: 22 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ror2 Mutation:  104 strains or lines available
References
Original:  J:60754 DeChiara TM, et al., Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nat Genet. 2000 Mar;24(3):271-4
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory