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Rr320tm1.1Mkg
Targeted Allele Detail
Summary
Symbol: Rr320tm1.1Mkg
Name: regulatory region 320; targeted mutation 1.1, Mark Groudine
MGI ID: MGI:2386946
Synonyms: deltaLCR, Hbb-artm1.1Mkg
Gene: Rr320  Location: Chr7:103501973-103526752 bp, + strand  Genetic Position: Chr7, Syntenic
Alliance: Rr320tm1.1Mkg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60714
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is derived from Rr320tm1Mgk. The 24 kb region of the gene containing 5' HS sites 1-6 flanked by loxP sites were removed by mating mutant animals to a cre-expressing line. Correct removal of the floxed sequence was confirmed by Southern blot analysis. (J:60714)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr320 Mutation:  0 strains or lines available
References
Original:  J:60714 Bender MA, et al., Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. Mol Cell. 2000 Feb;5(2):387-93
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory