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Transgene Detail
Symbol: Tg(FGFR3-G380R)7Aya
Name: transgene insertion 7, Avner Yayon
MGI ID: MGI:2386939
Synonyms: hFGFR-3G380R
Transgene: Tg(FGFR3-G380R)7Aya  Location: unknown  
Strain of Origin:  (BALB/c x C57BL/6)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(FGFR3-G380R)7Aya expresses 1 gene
Mutation detailsThe human FGFR3 gene carrying a glycine to arginine subsitution at amino acid 380 (G380R), a mutation found in the majority of achondroplasia patients, was fused to the mouse Fgfr3 promoter and first non-coding exon (-2311 to +156) and used as the transgene. RT-PCR analysis showed transgene expression in 16 day chondrocytes from transgenic embryos. The transgene expression pattern is similar to that of the endogenous protein as demonstrated by in situ hybridization analysis. (J:59887)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Founder 7 carrying low transgene copy numbers at a single integration site were used for analysis.
Original:  J:59887 Segev O, et al., Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice. Hum Mol Genet. 2000 Jan 22;9(2):249-58
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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