Inpp5d^tm1Rkh
Targeted Allele Detail

Summary

• Symbol: Inpp5d^tm1Rkh
• Name: inositol polyphosphate-5-phosphatase D; targeted mutation 1, R Keith Humphries
• MGI ID: MGI:2386884
• Synonyms: SHIP^-
• Gene: Inpp5d Location: Chr1:87548034-87648229 bp, + strand Genetic Position: Chr1, 44.44 cM, cytoband C5
• Alliance: Inpp5d^tm1Rkh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48193
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1 was replaced by the insertion of a double selection construct containing a neo cassette and a downstream Tk gene via homologous recombination. (J:48193)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inpp5d Mutation: 93 strains or lines available

References

• Original: J:48193 Helgason CD, et al., Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev. 1998 Jun 1;12(11):1610-20
• All: 61 reference(s)