About   Help   FAQ
Sdc4tm1Tmu
Targeted Allele Detail
Nomenclature
Symbol: Sdc4tm1Tmu
Name: syndecan 4; targeted mutation 1, Takashi Muramatsu
MGI ID: MGI:2386875
Synonyms: SD-4-, Syn4-, Synd4(-)
Gene: Sdc4  Location: Chr2:164424247-164443887 bp, - strand  Genetic Position: Chr2, 85.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60596
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-3 and part of exon 4 (encoding the ectodomain and 3 putative glycosaminoglycan attachment sites) were replaced with a neo-derived cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot and Western blot analysis of total kidney RNA and fibroblast lysates, respectively. (J:60596)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sdc4 Mutation:  21 strains or lines available
References
Original:  J:60596 Ishiguro K, et al., Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions. J Biol Chem. 2000 Feb 25;275(8):5249-52
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory