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Targeted Allele Detail
Symbol: Sdc4tm1Tmu
Name: syndecan 4; targeted mutation 1, Takashi Muramatsu
MGI ID: MGI:2386875
Synonyms: SD-4-, Syn4-, Synd4(-)
Gene: Sdc4  Location: Chr2:164424247-164443887 bp, - strand  Genetic Position: Chr2, 85.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:60596
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2-3 and part of exon 4 (encoding the ectodomain and 3 putative glycosaminoglycan attachment sites) were replaced with a neo-derived cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot and Western blot analysis of total kidney RNA and fibroblast lysates, respectively. (J:60596)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sdc4 Mutation:  22 strains or lines available
Original:  J:60596 Ishiguro K, et al., Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions. J Biol Chem. 2000 Feb 25;275(8):5249-52
All:  21 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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