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Targeted Allele Detail
Symbol: Gopctm1.1Tno
Name: golgi associated PDZ and coiled-coil motif containing; targeted mutation 1.1, Tetsuo Noda
MGI ID: MGI:2386794
Synonyms: GOPC-
Gene: Gopc  Location: Chr10:52337024-52382124 bp, - strand  Genetic Position: Chr10, 26.54 cM, cytoband B3
Ultrastructural analysis of spermatogenic cells from wild type and Gopctm1.1Tno/Gopctm1.1Tno mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:78599
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was excised from Gopctm1Tno by the in vivo expression of cre recombinase. A lacZ gene remained in place of exons 2, 2b, and 3. Neither of the two protein isoforms produced by the endogenous locus were detected in homozygous mutant mice by Western blot and immunohistochemical analyses. (J:78599)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gopc Mutation:  1 strain or line available
Original:  J:78599 Yao R, et al., Lack of acrosome formation in mice lacking a Golgi protein, GOPC. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11211-6
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory