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Xbp1tm1Glm
Targeted Allele Detail
Nomenclature
Symbol: Xbp1tm1Glm
Name: X-box binding protein 1; targeted mutation 1, Laurie H Glimcher
MGI ID: MGI:2386788
Synonyms: XBP-1-
Gene: Xbp1  Location: Chr11:5520659-5525893 bp, + strand  Genetic Position: Chr11, 3.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59916
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 0.8 kb genomic region between exons 1 and 2 was replaced with a neomycin resistance cassette via homologous recombination resulting in a shift in the downstream reading frame. Northern blot analysis of homozygous mutant embryos did not detect wild-type transcript, but instead detected a larger mutant transcript which contained the neo insert. Western blot of fetal livers did not detect protein product in homozygous mutants. (J:59916)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xbp1 Mutation:  8 strains or lines available
References
Original:  J:59916 Reimold AM, et al., An essential role in liver development for transcription factor XBP-1. Genes Dev. 2000 Jan 15;14(2):152-7
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory