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Targeted Allele Detail
Symbol: Esr1tm1.1Mma
Name: estrogen receptor 1 (alpha); targeted mutation 1.1, Manuel Mark
MGI ID: MGI:2386760
Synonyms: ERalpha-, ERalphaKO, ERalphaL-
Gene: Esr1  Location: Chr10:4611989-5005633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:64426
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe mutation is a derivative of Esr1tm1Mma. The floxed exon 3 and TK-neo cassette were deleted by mating Esr1tm1 animals to a cre-expressing line. Absence of gene expression was confirmed by Western blot and RT-PCR analysis of uterus protein and RNA from homozygous mutant animals. (J:64426, J:206373)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:  14 strains or lines available
Original:  J:64426 Dupont S, et al., Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development. 2000 Oct;127(19):4277-91
All:  97 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory