Tg(Myh6-cre)2182Mds
Transgene Detail

Nomenclature

Symbol:	Tg(Myh6-cre)2182Mds
Name:	transgene insertion 2182, Michael D Schneider
MGI ID:	MGI:2386742
Synonyms:	alphaMhc-Cre, alpha-MHC-Cre^+, alphaMyHC-Cre, MCH-cre, MHCalphaCre, MHCcre, MHC-Cre, Tg(Myhca-cre)2182Mds
Transgene:	Tg(Myh6-cre)2182Mds  Location: unknown

Sarcomere maturation is attenuated in Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0 hearts

Show the 6 phenotype image(s) involving this allele.

Transgene origin

Strain of Origin:

FVB/N

Transgene description

Transgene Type:		Transgenic (Recombinase)
Mutation:		Insertion
		Mutation details: The transgenic construct contained the Myh7 3' untranslated region, the Myhca promoter, Myhca noncoding exons 1 and 2, and the exon 3 splice acceptor site 180 bp upstream and driving the expression of the cre recombinase sequence. The Myhca promoter drives expression in cardiac tissue. (J:67908)

Generation of the Rheb^tm1.1Otsu allele

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myh6     Summary of all recombinase alleles driven by Myh6.

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available

References

Original:	J:67908 Agah R, et al., Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J Clin Invest. 1997 Jul 1;100(1):169-79
All:	181 reference(s)