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Targeted Allele Detail
Symbol: Pdha1tm1Ptl
Name: pyruvate dehydrogenase E1 alpha 1; targeted mutation 1, Mulchand S Patel
MGI ID: MGI:2386703
Synonyms: Pdha1flox8
Gene: Pdha1  Location: ChrX:160122209-160138413 bp, - strand  Genetic Position: ChrX, 73.95 cM, cytoband F3-F4
Germline Transmission:  Earliest citation of germline transmission: J:74192
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 8 was left flanked by loxP sites after a downstream floxed tk-neo cassette was excised by the in vitro expression of cre recombinase. Western blot analysis of homozygous mutant ES cells showed normal levels of both isoforms produced by the endogenous allele. Mice carrying this allele were bred to transgenic mice expressing cre in the germline to generate Pdha1tm1.1Ptl. (J:74192)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 21 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdha1 Mutation:  22 strains or lines available
Original:  J:74192 Johnson MT, et al., Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development. Mol Genet Metab. 2001 Nov;74(3):293-302
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory