Nkx2-3^tm1Hha
Targeted Allele Detail

Summary

• Symbol: Nkx2-3^tm1Hha
• Name: NK2 homeobox 3; targeted mutation 1, Hans-Henning Arnold
• MGI ID: MGI:2386680
• Synonyms: Nkx2.6^-
• Gene: Nkx2-3 Location: Chr19:43600764-43604331 bp, + strand Genetic Position: Chr19, 36.67 cM
• Alliance: Nkx2-3^tm1Hha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54198
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene was deleted and replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of RNA from the duodenum, jejunum, and colon of homozygous mutant animals did not detect gene expression. In situ hybridization of E9.5 homozygous mutant embryos also failed to detect gene transcripts. (J:54198)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-3 Mutation: 14 strains or lines available

References

• Original: J:54198 Pabst O, et al., Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. Development. 1999 May;126(10):2215-25
• All: 9 reference(s)