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Targeted Allele Detail
Symbol: Nkx2-3tm1Hha
Name: NK2 homeobox 3; targeted mutation 1, Hans-Henning Arnold
MGI ID: MGI:2386680
Synonyms: Nkx2.6-
Gene: Nkx2-3  Location: Chr19:43612325-43615892 bp, + strand  Genetic Position: Chr19, 36.67 cM
Germline Transmission:  Earliest citation of germline transmission: J:54198
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the gene was deleted and replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of RNA from the duodenum, jejunum, and colon of homozygous mutant animals did not detect gene expression. In situ hybridization of E9.5 homozygous mutant embryos also failed to detect gene transcripts. (J:54198)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-3 Mutation:  7 strains or lines available
Original:  J:54198 Pabst O, et al., Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. Development. 1999 May;126(10):2215-25
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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