About   Help   FAQ
Targeted Allele Detail
Symbol: Hif1atm3Rsjo
Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 3, Randall S Johnson
MGI ID: MGI:2386679
Synonyms: +f, Hif1a2lox, HIF1af+, Hif1afl, Hif1aloxP, Hif-1alpha 2-lox, HIF-1alpha+f, HIF-1alphaF, HIF1alphaflox, Hif+f, Hiff, I.1-lox
Gene: Hif1a  Location: Chr12:73901375-73947530 bp, + strand  Genetic Position: Chr12, 31.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:78980
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted in intron 1 and a floxed neomycin resistance cassette was placed in intron 2. Exon 2 was left flanked by loxP sites after the neo cassette was excised by in vitro expression of cre recombinase. (J:78980)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hif1a Mutation:  27 strains or lines available
Original:  J:78980 Ryan HE, et al., Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res. 2000 Aug 1;60(15):4010-5
All:  225 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory