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Targeted Allele Detail
Symbol: Hif1atm3Rsjo
Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 3, Randall S Johnson
MGI ID: MGI:2386679
Synonyms: +f, Hif1a2lox, HIF1af+, Hif1afl, Hif1aloxP, Hif-1alpha 2-lox, HIF-1alpha+f, HIF-1alphaF, HIF1alphaflox, Hif+f, Hiff, I.1-lox
Gene: Hif1a  Location: Chr12:73901375-73947530 bp, + strand  Genetic Position: Chr12, 31.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:78980
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted in intron 1 and a floxed neomycin resistance cassette was placed in intron 2. Exon 2 was left flanked by loxP sites after the neo cassette was excised by in vitro expression of cre recombinase. (J:78980)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 35 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Hif1a Mutation:  11 strains or lines available
Original:  J:78980 Ryan HE, et al., Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res. 2000 Aug 1;60(15):4010-5
All:  282 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory